After playing Winter ball with Lobos de Arecibo of the Liga de Beisbol Profesional de Puerto Rico,Butera made the Twins out of Spring training 2010. Drew made his major league debut on April 9, 2010 against the Chicago White Sox, and got his first major league hit against the Cleveland Indians on April 22, 2010. Drew hit his first MLB career home run in a 13-10 eleven-inning win against the Philadelphia Phillies on June 19th, 2010.
Spent entire season at Triple-A Rochester...went 3-for-4 with two rbi, May 6 at Louisville...hit his first Triple-A home run, June 24 vs. Columbus...went 3-for-4 with two doubles, August 10 at Buffalo...batted .256 (22-for-86) vs. lefties and .193 (41-for-212) vs. righties...finished second in the International League in caught stealing percentage, throwing out 40 of 96 (41.7%) potential base-stealers...tied for league lead in passed balls with 14...ranked the top defensive catcher in the International League by Baseball America.
Spent the entire year in the Eastern League with Double-A New Britain...went 2-for-3 with a walk in his first game April 3...scored a season-high three runs in a 3-for-5 effort, April 12 at Portland...had a season-high four-hit game, June 18 at Portland (two doubles, two runs scored)...hit .308 (30-for-65) over 21 games in June...recorded 11 multi-hit games, including four games with three-or-more hits...appeared in 96 games, including 92 as the Rock Cats catcher.
Began season at Single-A St. Lucie (Mets)...had four consecutive two-hit games, going 8-for-19 (.421), May 29-June 3...season-high three rbi, May 30 vs. Vero Beach...homered in consecutive games, May 30-31...promoted to Double-A Binghamton, June 22...hit safely in eight of nine games, June 27-July 7...was 7-for-19 (.368) in five games, July 14-19...acquired by Minnesota along with Dustin Martin, in exchange for second baseman Luis Castillo, July 30...assigned to Double-A New Britain and had season-high six-game hit-streak, going 7-for-20 (.350), August 5-20...tied season-high three hits, August 29 at Binghamton.
Hit .286 in 18 games in June...Went 16-56 with three doubles, two home runs and 11 RBI...Was 5-5 with two runs scored, a home run and three RBIs vs. Delmarva on June 10...Also had seven games with two hits...Knocked in three runs on two other occasions, April 16 vs. Lake County and July 7 vs. Lakewood...Last winter, he played for North Shore in the Hawaiian Winter League...Hit .232 (13-56) with five doubles and five RBIs in 21 games.
Made his professional debut with Brooklyn (A) of the New York-Penn League...Threw out 29 of 62 runners attempting to steal (47 percent).